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& Holmes, S

Nitric Oxide Pathway Studies Nitric oxide (NO) is a gas molecule that the bodys cells naturally produce

doi: 10.1136/bmj.321.7271.1237 [DOI] [PMC free article] [PubMed] [Google Scholar] 2

The resulting downregulation of JMJD3 leads to suppressed EDNRB expression and compensatory upregulation of EDNRA, promoting endothelin-mediated vasoconstriction, ERK pathway activation, and vascular remodelingall key features of hypertension [55,56,57]