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12) is greater than the rate constant of reactions of nitric oxide or superoxide with biological molecules (O 2 converted by SOD, k ~ 2 10 9 M 1 s 1 and NO interacting with hemoglobin, k ~ [56] 10 7 M 1 s 1 ) (Lewandowska 2013)

That's the million-dollar question, isn't it

Before supplementing, consult your doctor about appropriate dosing if you are taking a medication that impairs absorption (such as PPIs or diuretics) or if you have a condition that impairs excretion (such as kidney disease)

Crohn's disease, coeliac disease, and conditions affecting stomach or small intestine can impair B12 absorption regardless of dietary intake