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Even though NAD+ rises and sirtuins activate, there is no substrate available to oxidize

This is my first round, but already seeing it work

However, the progress is slow

References Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic The objective of this study was to evaluate the efficacy, onset of action, duration of action, and side effects of 1% diphenhydramine compared with 1% lidocaine when used as a local anesthetic agent