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However, survodutide has carved out a distinct position in MASH treatment with FDA Breakthrough Therapy Designation and dedicated Phase 3 MASH trials

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Upon HGF binding c-MET gets activated through kinase activity which is followed by receptor dimerization and trans-phosphorylation of two catalytic tyrosine residues Tyr1234 and Tyr1235 within the kinase activation region [31]