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Familial AD is usually correlated with mutations in 3 genes encoding amyloid precursor protein (APP) and the enzymatic components of -secretase complexes, including presenilin 1 (PS1) and presenilin 2 (PS2)

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Analogously, several miRNAs have shown an active interplay between cytosol and mitochondrial matrix ( Physical activity is known to influence nuclear epigenetics by increasing lifespan through activation of sirtuins, including the mitochondrial protein SIRT3 (114)