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doi: 10.1378/chest.127.1.308

10.1016/j.cell.2022.09.015 23 DongL.QinJ.TaiL.MouK.LiaoX.ChenF.et al

Therefore, reduced proinsulin-to-insulin conversion may also reflect changes in luminal acidification, for instance, due to premature ageing of secretory granules, since the pH of older granules is 6.2 (M