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In addition, the role of glucose metabolism impairment was observed in a meta-analysis encompassing more than 1,700,000 patients, finding diabetic patients to have a 38% higher risk of development of PD (Yue et al., 2016), while in another meta-analysis on 86,000 PD patients, prediabetic patients were found to have a 4% higher risk of development of PD compared to individuals with no fasting glucose impairment ( 2.4 Mitochondrial dysfunction Mitochondria are crucial for insulin secretion from pancreatic cells, and their dysfunction contributes to impaired insulin secretion in T2DM