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A threshold concept for cancer therapy

Although ART has substantially decreased opportunistic infections associated with HIV infection, pneumonias from these routine pathogens such as pneumococcus and influenza continue to cause significant morbidity and mortality in these susceptible individuals [4], [5]

Lentz SR, Malinow MR, Piegors DJ, Bhopatkar-Teredesai M, Faraci FM, and Heistad DD (1997)

Peroxynitrite and apoptosis Once the level of cellular damage inflicted by peroxynitrite supercedes any possibility of repair, the cell eventually dies via one of the two main pathways of cell demise, necrosis or apoptosis