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Journal Thyssen JP, Jellesen MS, Menn T, et al

We mainly discussed the potential etiology and pathogenesis of MDD from the perspective of widely accepted theories, including the neurotransmitter and receptor hypothesis, HPA axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis

doi: 10.3389/fphys.2026.1779008 Received 31 December 2025 Revised 17 February 2026 Accepted 19 February 2026 Published 09 March 2026 Volume 17 - 2026 Edited by Mohd Yaseen Malik, University of Oxford, United Kingdom Reviewed by Jerzy Beltowski, Medical University of Lublin, Poland Gabriel Komla Adzika, University of Pennsylvania, United States Updates Copyright 2026 Pena, Del Ro and Flores