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79 Evidence implicating the GI microbiota as the site of cyclamate metabolism are numerous: cyclamate was found to be converted to cyclohexamine in vitro by the contents of the lower gut but not by the tissues of rats pretreated with cyclamate

The mGlu4 receptor PAM, foliglurax, failed to improve motor symptoms in PD patients The highly potent and selective mGlu4 receptor PAM, PXT002331/foliglurax, showed a high brain exposure after oral administration 142 , and improved motor symptoms and LIDs in macaques challenged with MPTP 143

To elucidate the mode of cell death induced by MG, cells were treated with three inhibitors, and their effects on different modes of cell death were observed (Figure 4D)

Green B, Flores A, Warner J, Kohler T, Helo S, Trost L