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Cholesterol 7-hydroxylase (CYP7A1) is a rate-limiting enzyme that transforms cholesterol in non-hepatic peripheral tissues into bile acids (BAs) by catalyzing the synthesis of hepatic BAs (Ge et al., 2019)

Conclusions and perspective In summary, acute and chronic hypoxia induce a myriad of responses on a cellular level, and our understanding of how they are coordinated will continue to be investigated