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Pre-training involves using focal loss and a warm-up mechanism to address class imbalance and improve generalization

Melndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A, Crdenas ML

Rockville (2001) Guidance for industry bioanalytical method validation, US Department of Health and Human Services, US Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER)

Further, if coronary angioplasty is used to treat their severe atherosclerosis, diabetics are much more likely to have renarrowing of cardiac vessels, termed restenosis