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The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]

GSH participates in the conjugation and elimination of compounds, supporting natural detoxification pathways and contributing to the maintenance of a balanced liver environment

It can accumulate in various organs of the body, such as the liver and kidneys, causing various detrimental effects on human health

They may also use modalities such as ice or heat to reduce inflammation and pain