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In DCs, ROS production and lipid peroxidation promote the escape of antigens from endosomes into the cytoplasm so that the proteasome can be degraded into peptides and processed into MHC I (91)

History of approaches to the treatment of type 2 diabetesfrom then to now Following the first use of insulin as a therapeutic agent in 1922, there has been steady progress, with the introduction of eleven new classes of agents for treating hyperglycaemia in type 2 diabetes over the past half-century or so (Fig

NAC reduced mitochondrial ROS levels caused by 800 M CGA and improved L-02 cell activity (Figures 7G,H)

Lagier-Tourenne C and Cleveland DW