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Daratumumab for high-risk smoldering multiple myeloma FDA Approval Date: November 6, 2025 Daratumumab, an anti-CD38 monoclonal antibody, was approved as monotherapy for adults with high-risk smoldering multiple myeloma, marking a paradigm shift toward early immune intervention before symptomatic disease develops

Simvastatin, at appropriate concentrations, could promote NPMSC proliferation and induce the expression of NP cell-like ECM components, potentially via the hypoxia-inducible factor-1 signaling pathway ( Bioactive cytokines and enzymes have also been found to regulate NPMSC function

Shin K, Wang Q, Margolis B

Hepatic fibroblast growth factor 21 is regulated by PPAR and is a key mediator of hepatic lipid metabolism in Ketotic States