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10.1016/j.mad.2006.01.004 Mech

Under Section 503A of the Federal Food, Drug, and Cosmetic Act, compounding pharmacies can legally prepare individualized medications for patients with valid prescriptions provided the bulk drug substance they use meets one of three criteria: it appears on the FDA's Category 1 list of approved bulk substances, it has a USP/NF monograph, or it is a component of an FDA-approved drug

its hallmark feature is the uncontrolled, iron-dependent accumulation of lipid peroxides on cellular membranes (12), ultimately leading to the destruction of membrane integrity and cell death

Consequently, there is a need for molecular strategies that selectively disrupt NFAT dephosphorylation by Cn while potentially enabling Cns activity against other substrates