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The serious adverse events documented in HPS2-THRIVE (increased diabetes, infections, gastrointestinal problems, bleeding, and musculoskeletal complications) make high-dose nicotinic acid a risk that is difficult to justify without a clear clinical indication

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[6] Oral Dosing Guide Larazotide is an oral, luminally-acting peptide, so its dosing is a record of what appeared in the trials rather than a titration schedule and its most striking feature is an inverted dose-response, where the lowest maintenance dose is the one that worked