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(199) documented gut barrier damage with mucus layer alterations in T1D patients, which correlated with reduced abundance of SCFA-producing bacteria (e.g., CB )

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Compared to the recovered cases, there was a strong enrichment in upregulated terms for pathways related to T cell differentiation and activation (for example, PRDM1, TNF), TGF signaling (for example, SMAD3 , SNAI1 , SMURF1 ) and regulation of angiogenesis (for example, HES1 , DLL1 , HIF1A ), while there was downregulation in genes involved in platelet activation, signaling and aggregation (for example, PF4V1 , PF4 , TREML1 ) and hemostasis (for example, F13A1 , GP1BA , GP1BB ) (Fig