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A total of 43% of the world population is infected, and although often asymptomatic, it increases the probability of gastric cancer development and mucosa-associated lymphoma tissue owing to permanent inflammation 3

Moreover, whether the exosomes continuously secreted by the engineered cells, as a delivery vector themselves, will transfer the genetic modification effects laterally to distant tissue cells and thereby cause toxicity, is also an urgent issue that needs to be deeply clarified as a safety concern [168]

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