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Furthermore, elevated levels of pro-inflammatory interferon (IFN-), tumor necrosis factor (TNF-), and granzyme B (produced by CD8 + T cells) increased the IFN- level in the adipose tissue of middle-aged mice [11]

Hematology: Basic Principles and Practice

Crit Rev Food Sci Nutr 2019;59:2697-707

However, treating vitamin B12 deficiency can reduce fatigue and weakness, which may lead to an increased appetite in some individuals and indirectly contribute to weight gain