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An emerging aspect to keep in mind is that besides the prevalence of ALD, alcohol consumption also occurs in the context of obesity and MASLD, leading to a new paradigm where alcohol intake coexists with metabolic alterations and cardiovascular risks, coined MetALD and covered in the section Metabolic liver diseases, which accounts for most cases of chronic metabolic liver disease and alcohol consumption

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Researchers running high-dose protocols that deplete vials quickly face less stability concern, but those on lower doses like 1mg or 2mg may find that a single vial lasts close to the stability window, making careful date tracking essential