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To examine whether GSH/GSSG imaging is possible, we exposed lentivirally (lenti) transduced Grx1-roGFP2-hCM (Figure 4C) and Grx1-roGFP2-hFF (Figure 4D) to increasing concentrations of H 2 O 2 (0.11,000 mol/L) and DTT (0.011 mmol/L)

Physiological Effects of the Mitochondria: The healthy function of mitochondria is essential to life-sustaining metabolic processes, including: (1, 5) Regulating ion concentrations, such as calcium buffering critical to intracellular communication Maintain roles in fluctuating lipid levels Synthesizing products necessary for the transportation of glucose and insulin Providing sufficient energy for blood flow to and within the heart Regulating the removal of cellular damage or apoptosis if the condition is deleterious enough to the mitochondrions function Mitochondria Dysfunction and Health: Now that research has enlightened our concept of how the mitochondria are more than just energy generators, the medical community now has a new field of research to investigate how mitochondria functional defects adversely affect human health

PMID 15717864

PMID 19451637