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Nat Med 21(4):363376

Off-label applications are reported only by practitioners and require oversight by the care team

Intramuscular Administration When used intramuscularly, ME 12 Injection should not be repeatedly injected at the same place

Given the brains unique susceptibility to proteotoxic stress, owing to its post-mitotic neuronal population, high metabolic demand, and reliance on precise proteome regulation, UPS integrity is indispensable for neuronal survival