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Beyond the total mass, several quality variables sit outside the arithmetic: actual peptide purity (residual by-products, truncated sequences, counterion and water content that inflate apparent mass) and endotoxin or bioburden a sterility claim may not cover

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The actions of IGF-I and IGF-IR in skeletal development Skeletal development is a highly coordinated process, which requires initial recruitment and migration of relevant precursors to future bone sites, commitment of the precursors to chondrogenic and osteogenic lineages and their terminal differentiation to acquire a complete set of cartilage- or bone-forming functions (24,25)