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In colorectal cancer patients, co-treatment with Manuka honey (UMF 15+) and 5-fluorouracil (5-FU) increased intratumoral drug concentration by 62%, attributed to inhibition of efflux transporters such as P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) ( 4.7 Radioprotective effects and DNA repair Honey has shown radioprotective effects based on its ability to enhance DNA repair mechanisms and reduce oxidative damage in irradiated tissues

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Without sufficient glutathione, cells become more vulnerable to damage

Organic acids are a group of carbon-based compounds that exhibit acidic properties, most commonly due to the presence of carboxylic acid groups (COOH)