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Normal expression of GPx1, however, is associated overwhelmingly with protection, in that normal expression of GPx1 results in less severe consequences than conditions with GPx1 deficiency in many diseases and, in diseases where ROS-mediated damage plays a crucial role in the pathogenesis, excess GPx1 is beneficial

Accordingly, layers of smooth muscle cells play a critical role in both physiological and pathological processes, primarily due to the significant and interdependent effects of various signaling pathways that modulate smooth muscle activity (Giuseppe and Paul, 2015