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Ixazomib, on the other hand, was evaluated in early Phase I clinical trial (NCT02630030) for its ability to reach brain tumors due to its distinctive permeability to tumor tissues (95)

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Cell culture and assays Total B cells and FoB/MZB were magnetically enriched from mouse spleen using a B cell or MZ and FO B Cell Isolation Kit, respectively (Miltenyi Biotec 130-090-862 and 130-100-366) as per manufacturers protocol

Abstract Glutathione peroxidase (GPx) is a selenocysteine-containing peroxidase enzyme that defends mammalian cells against oxidative stress, but the role of GPx signaling is poorly characterized