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The reticulocyte count is increased and may reach peaks of 30% or greater, with an elevated percentage of the immature reticulocyte fraction, reflecting a prompt and effective bone marrow response

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The FDAs decision was supported by the Phase III SUNLIGHT trial, where the LonsurfAvastin combination led to a median overall survival of 10.8 months versus 7.5 months on Lonsurf monotherapy, for a 39% reduction in risk of death