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PRDX enzymes primarily regulate ROS generated during TCR signalling, rather than ROS produced during overt stress responses

Lai HJ, Zhan YQ, Qiu YX, Ling YH, Zhang XY, Chang ZN

Further studies linked the susceptibility to viral-induced myocarditis with a deficiency of GPx1, as GPx1 knockout (GPx1 / ) mice on a normal selenium diet were susceptible to viral-mediated myocarditis whereas wildtype (GPx1 +/+ ) mice were protected from viral-induced cardiac damage [28]

In addition, these investigations predominantly focused on the GBM subtype of brain cancer, thereby restricting the extrapolation of their findings to other histological subtypes