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To know and therefore take advantage of the biphasicity is important for those athletes who are engaged in more daily training sessions, or who otherwise have little time for recovery between a high intensity exercise and the subsequent one, less than 8 hours, in order to maximize glycogen synthesis and achieve the optimal performance during a second close exercise session

The age-related decline in melatonin and dampening of circadian rhythms likely contributes to sleep problems, metabolic and cognitive decline, and increased vulnerability to age-related diseases

International Immunopharmacology, 110 , Article 108993

In addition, inhibited Sirt4 affects the transport of long-chain fatty acids to the mitochondrial matrix, blocking carnitine palmitoyltransferase 1 and inducing senescent lipid metabolism abnormalities [99]