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The depot effect in subcutaneous adipose tissue isn't a limitation

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These phenotypic alterations were found in both normal and tumor organ arteries, indicating that they promote tumor cell local intravasation and extravasation, culminating in metastatic colonization [78]

174,175 Acute liver injury induced by carbon tetrachloride leads to activation of the Wnt/-catenin signalling pathway, which manifests as an increase in the level of the Wnt target gene AXIN2