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indicated that 40 days of HMB supplementation (3 g daily) attenuate inflammatory status by changes in circulating TNF [F-F ratio] ( F = 6.48, p = 0.006), CX3CL1 ( F = 4.70, p = 0.025), IL-1 ( F = 6.93, p = 0.006), IL-2 ( F = 4.96, p = 0.019), IL-6 ( F = 6.27, p = 0.012) and IL-10 ( F = 3.72, p = 0.041) plasma concentrations during highly intense military training [38]

Cell 184 , 53385356.e5321 (2021)

Figure 2 3.1 The metabolism of short chain fatty acids SCFAs, such as acetate (C2), propionate (C3), and butyrate (C4), are produced through the fermentation of dietary fibers and indigestible carbohydrates (such as resistant starch) by the gut microbiome (51)

TXNIP overexpression in mice enhances streptozotocin-induced diabetes severity