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Notably, the expression of VDRs was significantly downregulated by the natural occurrence of AFB 1 (at nM concentrations) in osteosarcoma cell line SaOs-2

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

In doing so, we intentionally force the model to learn to generate the effects of those local phenomena resolved by the dynamical numerical model, emulating its behavior