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Current research limitations include the absence of large-scale randomized clinical trials in humans, an still partial understanding of the precise molecular mechanisms, and a lack of detailed pharmacokinetic data in humans

These findings suggest that the efficacy of carvedilol may go beyond simple portal pressure control and involve multi-organ protection 97

These factors include alcohol consumption, precocious puberty, late menopause, first pregnancy in late age, a short period of breastfeeding, use of combined oestrogen and synthetic progestogen hormonal therapy, a high-fat diet, and little or lack of physical exercise

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