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This synergistic action is likely due to the photothermal activation of AuNRs, which not only disrupts the tumor microenvironment but also improves drug penetration and local cytotoxicity

Strong dual CYP3A4/P-gp inhibitors (ketoconazole, ritonavir, clarithromycin) can double apixaban exposure [1]

Acknowledgements The work of the author has been supported in part by grants AI072648 and AI122176 from the National Institutes of Health, the Phillips Lupus and Autoimmunity Centre of Excellence, and the Central New York Community Foundation

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