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Many studies suggested a relationship between acetylation phenotypes (in particular, arising from NAT2 genotypes) and the risk of various cancer including colorectal, liver, breast, prostate, head and neck (Agndez, 2008) and other disease conditions such as birth defects (Lammer et al., 2004) or neurodegenerative and autoimmune diseases (Ladero, 2008)

The biochemical, histological, and molecular analysis not only aligns with the in-silico analyses but also serves as a strong validation of our predictions about the direct interaction of the BCA, CoQ10, and PHL with the transcription factor Nrf2 and its related XMEs

The key ferroptosis molecule GPX1 gene can also protect against memory impairments induced by A (142) by activating the cAMP response element-binding protein/brain-derived neurotrophic factor (CREB/BDNF) signaling pathway dependent on M1-mAChR (Shin et al., 2021)