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Moreover, the observed drop in 2,3-DPG among patients with kidney failure may be due to metabolic acidosis (144) , a common condition in chronic kidney diseases (145)

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Consequently, researchers must carefully interpret in vitro studies when attempting to infer the roles of in vivo studies

Concerning class I HDACs, except for the distributions of HDAC3 both in the nucleus and cytoplasm, other enzymes in this category exhibit a rich expression in the nucleus