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180 A previous study revealed that PDHB knockout causes lactate accumulation by reducing pyruvate metabolism and suppressing genes related to muscle differentiation

Transcriptional activation regulation of HIF-1 Under normoxia, HIF-1 barely undergoes its difficult degradation process owing to the aforementioned protective factors and remains relatively stable, thus playing its role in downstream gene transcription activity

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Specifically, for Group 1 DEGs (common genes), the analysis identified pathways involved in Parkinsons disease, Huntingtons disease, and oxidative phosphorylation (Fig 5B), which contained genes that were mostly down-regulated by vB12 treatment (Table S2)