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DUSP expression and activation are regulated by gene variants [47], transcription regulation [48,49,50,51], and post-translational modification [36]

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Cyclic GMP-dependent protein kinase type I (cGKI) exerts a cytoprotective function, as cGKI-deficient mice exhibit anemia and splenomegaly due to accelerated erythrocyte clearanceunderscoring cGKIs capacity to buffer pro-eryptotic signals ( 2+ activity, and its activator pyrvinium pamoate further influences this process via activating Cl -sensitive Ca 2+ -permeable cation channels and inhibiting Ca 2+ -activated K + channels (Kucherenko et al., 2012

It also effectively prevents hospitalization and even death after exposure to the virus