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334 This process leads to the induction of T-cell anergy, cell death, the differentiation of CD4+ cells into Tregs and polarization of macrophages to acquire an immunosuppressive phenotype

Large-scale CRISPR-based screens have identified thousands of degron motifs, particularly at protein C-termini, regulated by Cullin-RING E3 ligase complexes such as CRL2 and CRL4