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In animal studies, target mutation HGF or MET, or both genes caused abnormalities that led to embryonic lethality [42]

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Apart from 5mC and 5hmC, there are other forms of methylation present throughout the human genome, such as N6-methyladenine (6 mA, involved in the development of different types of neoplasia, such as gastric and non-small-cell lung cancer [35, 36]), N4-methylcytosine (4mC, involved in the development of gastrointestinal cancer [37]), and the oxidation products 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC, possibly involved in the development of prostate cancer) [6, 18, 38]