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As we get older, we make less catalase

Researchers should consider these differences when designing clinical protocols to enhance the effectiveness of growth hormone therapies

doi: 10.1039/d0fo02778b 141 PerryRJPengLBarryNAClineGWZhangDCardoneRLet al

In contrast, the detrimental effect of mitophagy mostly occurs in scenarios of excessive activation or abnormal regulation: when cells encounter sustained and severe pathological stress (such as severe ischemia and severe inflammation), mitophagy is abnormally activated, which excessively degrades functionally normal mitochondria, leading to disorders of cellular energy metabolism, insufficient ATP synthesis, and simultaneous disruption of the normal proliferation and renewal balance of mitochondria in cells