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If redness, itching, swelling, or clear irritation appears, discontinue use

At epithelial surfaces, secreted and membrane-anchored oxidases of the DUOX family deliver H 2 O 2 into the mucosal milieu, where it supports barrier integrity, fuels lactoperoxidase-mediated antimicrobial chemistry and acts as a paracrine signal that coordinates wound closure and innate immune recruitment without triggering wholesale oxidative damage when spatially confined (Sarr et al

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Multiple experimental studies have demonstrated that curcumin attenuates ischemic and toxic renal injury by suppressing TLR4/NF-B activation, reducing oxidative stress, and downregulating pro-inflammatory cytokines, including IL-1, IL-6, and TNF- (Youn et al