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Indeed, 4-en-VPA is transformed through -oxidation to reactive intermediates such as 2-propyl-2, 4-pentadienoic acid (2, 4-dien-VPA) that are capable of depleting mitochondrial GSH, as suggested by rat studies [60]

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180,181,182 PAV-104 effectively reverses the induction of the IFN-I response by SARS-CoV-2, as well as the maturation of the nucleoprotein signaling pathway that is known to facilitate coronavirus replication