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Although mutation of -synuclein is not a requirement for neurotoxicity (Moussa et al., 2004), Ala30Pro and Ala53Thr mutants are commonly detected in early-onset PD (Petrucelli et al., 2008)

Given the evidence that a pulsatile pattern of GH secretion is important for many of its physiological actions, a strategy to augment physiological pulsatile GH secretion without inducing the side-effects of supraphysiological GH doses has been studied in HIV lipodystrophy with excess VAT and decreased endogenous GH secretion (144, 145)