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These features are consistent with the facial triad coordination environment found by crystallography with 2-3 additional H 2 O ligands (Table S3)
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25 A more recent Cochrane review of the pharmacologic treatment of low back pain (also not specific to lumbar spinal stenosis) found that NSAIDs, muscle relaxants, and opioids had a small effect on pain reduction, but use of muscle relaxants and opioids was complicated by a significant risk of adverse effects
