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During the differentiation process, the thymocytes migrate from the subcapsular layer of the lobule cortex to the medulla, where they undergo negative and positive selection

Overall, despite more studies are needed before drawing any conclusions, there are plenty of preliminary and promising evidence of the potential of probiotics (alone or in combination with prebiotics) for improving the clinical management of BD patients, as multiple studies have proven their benefits in mood, depressive symptoms and other mental health parameters [284, 308]

Manjari Tripathi: Nothing to disclose