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34 Another clue to the diagnosis is that patients with Wilson disease tend to develop Coombs-negative hemolytic anemia, which leads to a disproportionate elevation in aminotransferase levels, with aspartate aminotransferase being higher than alanine aminotransferase

Additionally, busulfan has been shown to accelerate the senescence process in murine bone marrow cells, thereby inhibiting their hematopoietic functions [68]