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doi: 10.1038/ajg.2012.219

For instance, in tumors harboring p53 72P variant, PSAT1 interacts competitively with the mutant without relying on its enzymatic function, promoting the nuclear import of peroxisome proliferator-activated receptor- coactivator 1 (PGC-1) and thereby increasing mitochondrial biogenesis, oxidative phosphorylation (OXPHOS), and TCA cycle processes (Fig

dos Santos AF, Fazeli G, Xavier da Silva TN, Friedmann Angeli JP

We discuss metabolism and detoxification strategies of heavy metals and metalloid, with emphasis on the use of transcriptomics, metabolomics, and proteomics