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However, both drugs have mechanisms of action besides inhibiting SLC7A11 and inducing ferroptosis: sorafenib is commonly used in cancer therapy as a multi-kinase inhibitor, whereas sulfasalazine is capable of blocking prostaglandin production and is commonly used for treating patients with arthritis

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Bamias G, Okazawa A, Rivera-Nieves J, Arseneau KO, De La Rue Sa, Pizarro TT, Cominelli F

doi: 10.3390/ijms18071544 7 LienECLyssiotisCAJuvekarAHuHAsaraJMCantleyLCet al

Serum iron levels are reduced by negatively regulating the expression of duodenal iron transporters (DMT1 and FPN1) and TfR1 ( 2+ and Fe 3+ )